­
­
­
­

Inventi Impact: Gene Medicines

Articles

  • Inventi:pgm/31396/20
    Functional Polymorphisms and Gene Expression of TLR9 Gene as Protective Factors for Nasopharyngeal Carcinoma Severity and Progression
    Research 2020 : April - June
    Macherki Yosra, Souissi Sameh, Ghedira Randa, Remadi Yassmine, Gabbouj Sallouha, Bouzid Nadia, Bouaouina Noureddine, Zakhama Abdelfattah, Hassen Elham

    Nasopharyngeal carcinoma (NPC) is a disease that is closely associated with EBV infection. Toll-like receptor 9 is an\nimportant factor mediating the interaction between EBV and the host immune response. Any genetic (single nucleotide\npolymorphisms, SNPs) or expression variation in TLR9 gene may modify the ability of the receptor to respond correctly\nto viral infection as in NPC. This study is aimed at evaluating the effect of TLR9 functional polymorphisms (TLR9-1486\nT/C and TLR9-1237 T/C) and TLR9 mRNA expression in NPC severity and progression at diagnosis and after treatment.\nThis study included 322 patients with NPC. RFLP-PCR and real-time PCR were used to assess, respectively, the genotypes\nand the mRNA expression of TLR9 gene. ...........................

    How to Cite this Article
    Attribution/ CC Compliant Citation: Yosra, Macherki, et al.\n\"Functional Polymorphisms and Gene Expression of TLR9\nGene as Protective Factors for Nasopharyngeal Carcinoma\nSeverity and Progression.\" Journal of Immunology\nResearch 2019 (2019).\nhttps://doi.org/10.1155/2019/2826563\nhttp://creativecommons.org/licenses/by/4.0/\nSome formatting elements, header, footer, logos, dates and\npagination were modified while adapting this article.
    Download Full Text